منابع مشابه
Endothelial cell heterogeneity.
OBJECTIVE To review recent advances in the field of endothelial cell heterogeneity, and to apply this knowledge to an understanding of site-specific vasculopathy, including acute lung injury. DATA SOURCES AND STUDY SELECTION Published research and review articles in the English language related to endothelial cell biology and endothelial cell heterogeneity. DATA EXTRACTION AND SYNTHESIS The...
متن کاملHeterogeneity of bronchial endothelial cell permeability.
In vivo models of airway inflammation suggest that most protein transudation occurs from bronchial microcirculation. However, due to technical limitations in the isolation and culture of bronchial endothelial cells, most studies of lung vascular permeability have focused on pulmonary endothelium. Thus conditions for culture of sheep bronchial artery endothelial cells (BAEC) and bronchial microv...
متن کاملOcular Vascular Endothelial Heterogeneity
Endothelial cells form the lining of the vasculature. Despite the continuity of this layer throughout the body, endothelial cells exhibit remarkable heterogeneity in structure, molecular composition and activity: between sites; and in response to different exposures. One important consequence of endothelial diversity is the localized nature of many vascular disorders. To date a limited number o...
متن کاملMolecular and cellular determinants of lung endothelial cell heterogeneity.
Idiopathic pulmonary arterial hypertension is a progressive and potentially fatal disease with a limited number of therapeutic options. Two key lesions underlie the pathophysiology of this disease. The principal lesion is found in large- and intermediate-sized blood vessels and is characterized by medial and adventitial hypertrophy/hyperplasia, with distal extension of smooth-muscle layers into...
متن کاملMechanisms of endothelial cell heterogeneity in health and disease.
The endothelium is an expansive spatially distributed organ.1 Endothelial cells participate in a large number of physiological processes including the control of vasomotor tone, the trafficking of cells and nutrients, the regulation of permeability, and the maintenance of blood fluidity. In addition, the endothelium mediates new blood vessel formation, contributes to the balance of proand antii...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2011
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a006429